Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.

@article{Jacobs2010ImpairedDN,
  title={Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.},
  author={Ren{\'e} L Jacobs and Yang Zhao and Debby P. Y. Koonen and Torunn Sletten and Brian W. Su and Susanne Lingrell and Guoqing Cao and David A. Peake and Ming-shang Kuo and Spencer D. Proctor and Brian P. Kennedy and Jason R. B. Dyck and Dennis E. Vance},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 29},
  pages={22403-13}
}
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic PC biosynthesis is linked to diet-induced obesity. Pemt(+/+) mice fed a high fat diet for 10 weeks increased in body mass by 60% and displayed insulin resistance, whereas Pemt(-/-) mice did not… CONTINUE READING

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