Impaired cytolytic activity in peripheral blood T cells from renal cell carcinoma patients.

Abstract

Classic T lymphocyte cytotoxicity is mediated through the T cell receptor (TCR). Defects in TCR signal transduction and cytolytic activity have been reported in tumor infiltrating T lymphocytes. We hypothesized that impaired cytotoxicity occurs in peripheral blood T cells from renal cell carcinoma (RCC) that can be reversed by exposure to rhIL-2. Peripheral… (More)

Topics

Cite this paper

@article{Crocenzi2005ImpairedCA, title={Impaired cytolytic activity in peripheral blood T cells from renal cell carcinoma patients.}, author={Todd S Crocenzi and Christopher P.G. Tretter and Thomas Schwaab and Alan R. Schned and John A. Heaney and Bernard Cole and Jan L. Fisher and Marc S. Ernstoff}, journal={Clinical immunology}, year={2005}, volume={117 1}, pages={6-11} }