Impaired cutaneous permeability barrier function, skin hydration, and sphingomyelinase activity in keratin 10 deficient mice.

@article{Jensen2000ImpairedCP,
  title={Impaired cutaneous permeability barrier function, skin hydration, and sphingomyelinase activity in keratin 10 deficient mice.},
  author={Jan M{\o}ller Jensen and Stephan Sch{\"u}tze and Claudia Neumann and Ehrhardt Proksch},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={115 4},
  pages={
          708-13
        }
}
Point mutations in the suprabasal cytokeratins 1 (K1) or 10 (K10) in humans have been shown to be the cause of the congenital ichthyosis epidermolytic hyperkeratosis. Recently, a K10 deficient mouse model was established serving as a model for epidermolytic hyperkeratosis. Homozygotes suffered from severe skin fragility and died shortly after birth. Heterozygotes developed hyperkeratosis with age. To see whether phenotypic abnormalities in the mouse model were associated with changes in skin… CONTINUE READING
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