Impaired clearance of dying cells in systemic lupus erythematosus.

  title={Impaired clearance of dying cells in systemic lupus erythematosus.},
  author={Udo S Gaipl and Reinhard Edmund Voll and Ahmed U Sheriff and Sandra Franz and Joachim. R. Kalden and Martin Herrmann},
  journal={Autoimmunity reviews},
  volume={4 4},
Impaired clearance of apoptotic cell material has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Besides many other molecules, C1q and DNaseI contribute to an efficient clearance of dying cells. A frequently observed factor in SLE patients is the accumulation of unusually large amounts of apoptotic cells in various tissues. We showed that in a subgroup of patients with SLE, apoptotic cells accumulated in the germinal centers of the lymph nodes. The numbers of… CONTINUE READING


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