Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery.

@article{Kriangkum2006ImpairedCS,
  title={Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery.},
  author={Jitra Kriangkum and Brian J. Taylor and Erin R Strachan and Michael J. Mant and T. H. Reiman and Andrew R. Belch and Linda M. Pilarski},
  journal={Blood},
  year={2006},
  volume={107 7},
  pages={2920-7}
}
Analysis of clonotypic isotype class switching (CSR) in Waldenström macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (MGUS) reveals a normal initial phase of B-cell activation as determined by constitutive and inducible expression of activation-induced cytidine deaminase (AID). Switch mu (Smu) analysis shows that large deletions are not common in WM or IgM MGUS. In CD40L/IL-4-stimulated WM cultures from 2 patients, we observed clonotypic IgG exhibiting… CONTINUE READING
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