Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

@article{Sne2013ImpairedCE,
  title={Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.},
  author={Abdoulaye S{\'e}ne and Aslam Ali Khan and Douglas P. Cox and Rei E. I. Nakamura and Andrea Santeford and Bryan M. Kim and Rohini Sidhu and Michael D Onken and J. William Harbour and Shira Hagbi-Levi and Itay Chowers and Peter A. Edwards and {\'A}ngel Bald{\'a}n and John S Parks and Daniel S Ory and Rajendra S Apte},
  journal={Cell metabolism},
  year={2013},
  volume={17 4},
  pages={
          549-61
        }
}
Pathologic angiogenesis mediated by abnormally polarized macrophages plays a central role in common age-associated diseases such as atherosclerosis, cancer, and macular degeneration. Here we demonstrate that abnormal polarization in older macrophages is caused by programmatic changes that lead to reduced expression of ATP binding cassette transporter ABCA1. Downregulation of ABCA1 by microRNA-33 impairs the ability of macrophages to effectively efflux intracellular cholesterol, which in turn… CONTINUE READING

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