Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release.

@article{Sadakata2007ImpairedCD,
  title={Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release.},
  author={Tetsushi Sadakata and Wataru Kakegawa and Akira Mizoguchi and Miwa Washida and Ritsuko Katoh-Semba and Fumihiro Shutoh and Takehito Okamoto and Hisako Nakashima and Kazushi Kimura and Mika Tanaka and Yukiko Sekine and Shigeyoshi Itohara and Michisuke Yuzaki and Soichi Nagao and Teiichi Furuichi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 10},
  pages={2472-82}
}
Ca2+-dependent activator protein for secretion 2 (CAPS2/CADPS2) is a secretory granule-associated protein that is abundant at the parallel fiber terminals of granule cells in the mouse cerebellum and is involved in the release of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF), both of which are required for cerebellar development. The human homolog gene on chromosome 7 is located within susceptibility locus 1 of autism, a disease characterized by several cerebellar… CONTINUE READING

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