Impaired cardiac mitochondrial function and contractile reserve following an acute exposure to environmental particulate matter.

@article{Marchini2013ImpairedCM,
  title={Impaired cardiac mitochondrial function and contractile reserve following an acute exposure to environmental particulate matter.},
  author={Timoteo Marchini and Natalia D Magnani and Ver{\'o}nica D'Annunzio and Deborah Ruth Tasat and Ricardo Jorge Gelpi and Silvia {\'A}lvarez and Pablo Evelson},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1830 3},
  pages={2545-52}
}
BACKGROUND It has been suggested that mitochondrial function plays a central role in cardiovascular diseases associated with particulate matter inhalation. The aim of this study was to evaluate this hypothesis, with focus on cardiac O2 and energetic metabolism, and its impact over cardiac contractility. METHODS Swiss mice were intranasally instilled with either residual oil fly ash (ROFA) (1.0 mg/kg body weight) or saline solution. After 1, 3 or 5 h of exposure, O2 consumption was evaluated… CONTINUE READING
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