Impaired capillary hemodynamics in skeletal muscle of rats in chronic heart failure.

@article{Kindig1999ImpairedCH,
  title={Impaired capillary hemodynamics in skeletal muscle of rats in chronic heart failure.},
  author={Casey A. Kindig and Timothy I Musch and Randall J Basaraba and David C Poole},
  journal={Journal of applied physiology},
  year={1999},
  volume={87 2},
  pages={
          652-60
        }
}
Skeletal muscle blood flow is reduced and O(2) extraction is increased at rest in chronic heart failure (CHF). Knowledge of red blood cell (RBC) flow distribution within the capillary network is necessary for modeling O(2) delivery and exchange in this disease. Intravital microscopy techniques were used to study the in vivo spinotrapezius muscle microcirculation in rats with CHF 7 wk after myocardial infarction and in sham-operated controls (sham). A decrease in mean muscle fiber width from 51… CONTINUE READING
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