Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio.

@article{Kiviranta2005ImpairedBR,
  title={Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio.},
  author={Riku Kiviranta and Jukka P Morko and Sari L. Alatalo and R Nicamhlaoibh and Juha P Risteli and Tiina K Laitala-Leinonen and E. Vuorio},
  journal={Bone},
  year={2005},
  volume={36 1},
  pages={159-72}
}
Previous reports indicate that mice deficient for cathepsin K (Ctsk), a key protease in osteoclastic bone resorption, develop osteopetrosis due to their inability to properly degrade organic bone matrix. Some features of the phenotype of Ctsk knockout mice, however, suggest the presence of mechanisms by which Ctsk-deficient mice compensate for the lack of cathepsin K. To study these mechanisms in detail, we generated Ctsk-deficient (Ctsk-/-) mice and analyzed them at the age of 2, 7, and 12… CONTINUE READING
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