Impaired bone formation in transgenic mice resulting from altered integrin function in osteoblasts.

@article{Zimmerman2000ImpairedBF,
  title={Impaired bone formation in transgenic mice resulting from altered integrin function in osteoblasts.},
  author={Deborah L. Zimmerman and Fuzi Jin and Phoeby Leboy and Sara Hardy and Caroline C Damsky},
  journal={Developmental biology},
  year={2000},
  volume={220 1},
  pages={2-15}
}
To determine the role of integrins in mature osteoblasts in vivo, we expressed in transgenic mice a dominant-negative integrin subunit (beta1-DN) consisting of the beta1 subunit cytoplasmic and transmembrane domains, driven by the osteoblast-specific osteocalcin promoter. Immature osteoblasts isolated from transgenic animals differentiated normally in vitro until the osteocalcin promoter became active; thereafter they detached from the substratum, suggesting that beta1-DN was impairing adhesion… CONTINUE READING
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