Impaired beta-cell function in the presence of reduced insulin sensitivity determines glucose tolerance status in acromegalic patients.

@article{Kasayama2000ImpairedBF,
  title={Impaired beta-cell function in the presence of reduced insulin sensitivity determines glucose tolerance status in acromegalic patients.},
  author={Soji Kasayama and Michio Otsuki and Miki Takagi and H. Saito and Satoru Sumitani and Haruhiko Kouhara and Masafumi Koga and Yuhji Saitoh and Tetsuro Ohnishi and Norio Arita},
  journal={Clinical endocrinology},
  year={2000},
  volume={52 5},
  pages={
          549-55
        }
}
OBJECTIVE Abnormal glucose tolerance is often demonstrated in acromegalic patients. Although insulin resistance is a common feature of acromegaly, it remains unclear whether the extent of insulin resistance per se determines the abnormal glucose tolerance. In order to elucidate this issue, we investigated insulin sensitivity and beta-cell function in acromegalic patients. DESIGN Twenty-four acromegalic patients were studied in comparison with 24 healthy control subjects. To estimate insulin… CONTINUE READING
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