Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae.

@article{Boelen2009ImpairedBC,
  title={Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae.},
  author={Anita Boelen and Joan Kwakkel and Catharina Wilhelmina Wieland and Donald L. St. Germain and Eric Fliers and Arturo Hernandez},
  journal={Endocrinology},
  year={2009},
  volume={150 4},
  pages={1984-90}
}
The activation of type 3 deiodinase (D3) has been postulated to play a role in the reduction of thyroid hormone levels during illness. Using a mouse model of acute bacterial infection, we have recently demonstrated marked D3 immunostaining in neutrophils infiltrating infected organs. These observations suggest a possible additional role for this enzyme in the innate immune response. To further assess the role of D3 in the response to acute bacterial infection, we used null D3 [D3 knockout (D3KO… CONTINUE READING

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