Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation

@inproceedings{Liu2015ImpairedAI,
  title={Impaired autophagy in mouse embryonic fibroblasts null for Kr{\"u}ppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation},
  author={Changchang Liu and Elise P. DeRoo and Catherine Stecyk and Margaret Wolsey and Mateusz Szuchnicki and Engda G. Hagos},
  booktitle={Molecular Cancer},
  year={2015}
}
BackgroundAutophagy is a major cellular process by which cytoplasmic components such as damaged organelles and misfolded proteins are recycled. Although low levels of autophagy occur in cells under basal conditions, certain cellular stresses including nutrient depletion, DNA damage, and oxidative stress are known to robustly induce autophagy. Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor activated during oxidative stress to maintain genomic stability. Both autophagy and… CONTINUE READING
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