Impaired antioxidant activity of high-density lipoprotein in chronic kidney disease.

  title={Impaired antioxidant activity of high-density lipoprotein in chronic kidney disease.},
  author={Hamid Moradi and Madeleine Valdes Pahl and Reza Elahimehr and Nosratola D. Vaziri},
  journal={Translational research : the journal of laboratory and clinical medicine},
  volume={153 2},
Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and increased mortality from cardiovascular disease. CKD results in oxidative stress, inflammation, and high-density lipoprotein (HDL) deficiency, which work in concert to promote atherosclerosis. Normal HDL confers protection against atherosclerosis by inhibiting the oxidation of lipids and lipoproteins and by retrieving surplus cholesterol and phospholipids from lipid-laden cells in the artery wall for disposal in the… CONTINUE READING


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