Impaired antibody responses in the hyperimmunoglobulin E syndrome.

  title={Impaired antibody responses in the hyperimmunoglobulin E syndrome.},
  author={Donald Y. M. Leung and Donna M. Ambrosino and Robert D. Arbeit and Julia L. Newton and Raif S Geha},
  journal={The Journal of allergy and clinical immunology},
  volume={81 6},
Patients with the hyper-IgE (HIE) syndrome have recurrent bacterial infections with Staphylococcus aureus and other polysaccharide encapsulated organisms. To determine whether an impairment of the antibody response to polysaccharide antigens contributes to infections in this syndrome, we measured serum antibody to the teichoic acid of S. aureus and to the capsular polysaccharide of Haemophilus influenzae type b. Compared to control subjects who had no history of S. aureus infections (N = 14… CONTINUE READING


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