Impaired antibody responses but normal proliferation of specific CD4+ T cells in mice lacking complement receptors 1 and 2.

Fredrika Carlsson, Andrew Getahun, Christian Rutemark, B Heyman
Published 2009 in Scandinavian journal of immunology

Abstract

Severely impaired Ab responses are seen in animals lacking C (complement) factors C2, C3 or C4 as well as CR1/2 (C receptors 1 and 2). The molecular mechanism behind this phenomenon is not understood. One possibility is that C-containing immune complexes are endocytosed via CR2 on B cells and presented to specific CD4+ T cells, which would then proliferate… (More)

DOI: 10.1111/j.1365-3083.2009.02274.x

Requirement for complement in antibody responses is not explained by the classic pathway activator IgM.

Christian Rutemark, Elisabeth Alicot, +5 authors Birgitta Heyman
Proceedings of the National Academy of Sciences…
2011

Impaired antibody responses but normal proliferation of specific CD4+ T cells in mice lacking complement receptors 1 and 2.

Abstract

Topics

5 Figures and Tables

Cited By

Complement-Activating IgM Enhances the Humoral but Not the T Cell Immune Response in Mice

IgM and Its Receptors and Binding Proteins

EBI2 augments Tfh cell fate by promoting interaction with IL2-quenching dendritic cells

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors

Murine complement receptor 1 is required for germinal center B cell maintenance but not initiation.

Optimal Germinal Center B Cell Activation

Complement Receptors 1 and 2 in Murine Antibody Responses to IgM-Complexed and Uncomplexed Sheep Erythrocytes

Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists.

IgE-Mediated Enhancement of CD4+ T Cell Responses in Mice Requires Antigen Presentation by CD11c+ Cells and Not by B Cells

Requirement for complement in antibody responses is not explained by the classic pathway activator IgM.

References

A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen.

Follicular shuttling of marginal zone B cells facilitates antigen transport

Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells.

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

IgE enhances antibody and T cell responses in vivo via CD23+ B cells.

IgG- and IgE-mediated antigen presentation on MHC class II.

Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells.

Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection

Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses.

Modeling the presentation of C3d-coated antigen by B lymphocytes: enhancement by CR1/2-BCR co-ligation is selective for the co-ligating antigen.

Slides referencing similar topics

Impaired antibody responses but normal proliferation of specific CD4+ T cells in mice lacking complement receptors 1 and 2.

Abstract

Topics

5 Figures and Tables

Cited By

Complement-Activating IgM Enhances the Humoral but Not the T Cell Immune Response in Mice

IgM and Its Receptors and Binding Proteins

EBI2 augments Tfh cell fate by promoting interaction with IL2-quenching dendritic cells

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors

Murine complement receptor 1 is required for germinal center B cell maintenance but not initiation.

Optimal Germinal Center B Cell Activation

Complement Receptors 1 and 2 in Murine Antibody Responses to IgM-Complexed and Uncomplexed Sheep Erythrocytes

Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists.

IgE-Mediated Enhancement of CD4+ T Cell Responses in Mice Requires Antigen Presentation by CD11c+ Cells and Not by B Cells

Requirement for complement in antibody responses is not explained by the classic pathway activator IgM.

References

A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen.

Follicular shuttling of marginal zone B cells facilitates antigen transport

Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells.

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

IgE enhances antibody and T cell responses in vivo via CD23+ B cells.

IgG- and IgE-mediated antigen presentation on MHC class II.

Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells.

Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection

Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses.

Modeling the presentation of C3d-coated antigen by B lymphocytes: enhancement by CR1/2-BCR co-ligation is selective for the co-ligating antigen.

Similar Papers

Slides referencing similar topics