Impaired antibody responses but normal proliferation of specific CD4+ T cells in mice lacking complement receptors 1 and 2.


Severely impaired Ab responses are seen in animals lacking C (complement) factors C2, C3 or C4 as well as CR1/2 (C receptors 1 and 2). The molecular mechanism behind this phenomenon is not understood. One possibility is that C-containing immune complexes are endocytosed via CR2 on B cells and presented to specific CD4+ T cells, which would then proliferate… (More)
DOI: 10.1111/j.1365-3083.2009.02274.x


5 Figures and Tables