Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

@article{Maes2000ImpairedAA,
  title={Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188},
  author={Christa Maes and Peter Carmeliet and Karen Moermans and Ingrid Stockmans and Nico Smets and D{\'e}sir{\'e} Collen and R. Bouillon and Geert Carmeliet},
  journal={Mechanisms of Development},
  year={2000},
  volume={111},
  pages={61-73}
}
Vascular endothelial growth factor (VEGF)-mediated angiogenesis is an important part of bone formation. To clarify the role of VEGF isoforms in endochondral bone formation, we examined long bone development in mice expressing exclusively the VEGF120 isoform (VEGF120/120 mice). Neonatal VEGF120/120 long bones showed a completely disturbed vascular pattern, concomitant with a 35% decrease in trabecular bone volume, reduced bone growth and a 34% enlargement of the hypertrophic chondrocyte zone of… CONTINUE READING

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