Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects.

@article{Bories2012ImpairedAM,
  title={Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects.},
  author={Gael Bories and Robert Caiazzo and Bruno Derudas and Corinne Copin and Violeta Raverdy and M Pigeyre and François Pattou and Bart Staels and Giulia Chinetti-Gbaguidi},
  journal={Diabetes & vascular disease research},
  year={2012},
  volume={9 3},
  pages={189-95}
}
Visceral obesity is a chronic, low-grade inflammatory disease that predisposes people to the metabolic syndrome, type 2 diabetes and its cardiovascular complications. Adipose tissue is not a passive storehouse for fat, but an endocrine organ synthesizing and releasing a variety of bioactive molecules, some of which are produced by infiltrated immune-inflammatory cells including macrophages. Two different subpopulations of macrophages have been identified in adipose tissue: pro-inflammatory… CONTINUE READING

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