Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease

@inproceedings{Kohl2010ImpairedAO,
  title={Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease},
  author={Zacharias Kohl and Martin Regensburger and Robert Aigner and Mahesh Kandasamy and Beate Winner and Ludwig Aigner and J{\"u}rgen Winkler},
  booktitle={BMC Neuroscience},
  year={2010}
}
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder linked to expanded CAG-triplet nucleotide repeats within the huntingtin gene. Intracellular huntingtin aggregates are present in neurons of distinct brain areas, among them regions of adult neurogenesis including the hippocampus and the subventricular zone/olfactory bulb system. Previously, reduced hippocampal neurogenesis has been detected in transgenic rodent models of HD. Therefore, we hypothesized that mutant… CONTINUE READING
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