Impaired activation of oxygen consumption and blood flow in visual cortex of patients with mitochondrial encephalomyopathy.

Abstract

A current hypothesis claims that an increase of blood flow is required for oxygen consumption to rise during neuronal excitation (activation). Chronic progressive external ophthalmoplegia is a mitochondrial disease associated with deletions of mtDNA or by point mutation of tRNA genes. We tested the hypothesis that the cerebral metabolic rate of oxygen… (More)

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