Impaired activation of islet-reactive CD4 T cells in pancreatic lymph nodes of B cell-deficient nonobese diabetic mice.

@article{Greeley2001ImpairedAO,
  title={Impaired activation of islet-reactive CD4 T cells in pancreatic lymph nodes of B cell-deficient nonobese diabetic mice.},
  author={Siri Atma S. Greeley and Daniel J. Moore and Hooman Noorchashm and Lauren E. Noto and Susan Y. Rostami and Alexander Schlachterman and Howard K. Song and Brigitte Koeberlein and Clyde F. Barker and Ali Naji},
  journal={Journal of immunology},
  year={2001},
  volume={167 8},
  pages={4351-7}
}
Despite the impressive protection of B cell-deficient (muMT(-/-)) nonobese diabetic (NOD) mice from spontaneous diabetes, existence of mild pancreatic islet inflammation in these mice indicates that initial autoimmune targeting of beta cells has occurred. Furthermore, muMT(-/-) NOD mice are shown to harbor a latent repertoire of diabetogenic T cells, as evidenced by their susceptibility to cyclophosphamide-induced diabetes. The quiescence of this pool of islet-reactive T cells may be a… CONTINUE READING

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