Impaired Virus Clearance, Compromised Immune Response and Increased Mortality in Type 2 Diabetic Mice Infected with West Nile Virus

@inproceedings{Kumar2012ImpairedVC,
  title={Impaired Virus Clearance, Compromised Immune Response and Increased Mortality in Type 2 Diabetic Mice Infected with West Nile Virus},
  author={M. M. Swathanthira Kumar and Kelsey Roe and Pratibha V. Nerurkar and Madhuri Shailesh Namekar and Beverly Orillo and Saguna Verma and Vivek R Nerurkar},
  booktitle={PloS one},
  year={2012}
}
Clinicoepidemiological data suggest that type 2 diabetes is associated with increased risk of West Nile virus encephalitis (WNVE). However, no experimental studies have elucidated the role of diabetes in WNV neuropathogenesis. Herein, we employed the db/db mouse model to understand WNV immunopathogenesis in diabetics. Nine-week old C57BL/6 WT and db/db mice were inoculated with WNV and mortality, virus burden in the periphery and brain, and antiviral defense responses were analyzed. db/db mice… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

A guinea pig model of Zika virus infection

VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Inflammatory process in type 2 diabetes: The role of cytokines.

  • Annals of the New York Academy of Sciences
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL