Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

  title={Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease},
  author={Joshua L. Plotkin and Michelle C. Day and Jayms D. Peterson and Zhong Cong Xie and Geraldine J. Kress and Igor V Rafalovich and Jyothisri Kondapalli and Tracy S. Gertler and Marc Flajolet and Paul Greengard and Mihaela A. Stavarache and Michael G. Kaplitt and Jim Rosinski and C Savio Chan and D. James Surmeier},
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed to striatal degeneration induced by the loss of cortically supplied brain-derived neurotrophic factor (BDNF). Here, we show that in mouse models of early symptomatic HD, BDNF delivery to the striatum and its activation of tyrosine-related kinase B (TrkB) receptors were normal. However, in striatal neurons responsible for movement… CONTINUE READING
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Imbalance of p75(NTR)/TrkB protein expression in Huntington’s disease: implication for neuroprotective therapies

  • V. Brito, M. Puigdellı́vol, A. Giralt, D. del Toro, J. Alberch, S. Ginés
  • Cell Death Dis
  • 2013
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