Impaired TLR-2 expression and TLR-2-mediated cytokine secretion in macrophages from patients with atopic dermatitis.

@article{Niebuhr2009ImpairedTE,
  title={Impaired TLR-2 expression and TLR-2-mediated cytokine secretion in macrophages from patients with atopic dermatitis.},
  author={Margarete Niebuhr and Carolin Lutat and Stefanie Sigel and Thomas T Werfel},
  journal={Allergy},
  year={2009},
  volume={64 11},
  pages={1580-7}
}
BACKGROUND In many patients with atopic dermatitis (AD), the disease is complicated by their enhanced susceptibility to bacterial skin infections, especially with Staphylococcus aureus. The pattern recognition receptor toll-like receptor (TLR)-2 recognizes components of S. aureus, for example, lipoteichoic acid (LTA) and peptidoglycan (PGN) and, therefore, might be crucial in the pathogenesis and flare-ups of AD. OBJECTIVE To investigate TLR-2 expression and cytokine secretion in macrophages… CONTINUE READING

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