Impaired T cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice

  title={Impaired T cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice},
  author={M. Y. Park and Neetu Srivastava and Raki Sudan and D. R. Viernes and J. D. Chisholm and R W Engelman and W. G. Kerr},
  booktitle={Mucosal Immunology},
T cells have a critical role in immune surveillance at mucosal surfaces. SHIP1−/− mice succumb to mucosal inflammatory disease that afflicts the lung and small intestine (SI). The basis of this condition has not been defined. Here we show that SHIP1 is required for the normal persistence and survival of T cells in mucosal tissues. We find that CD4 and CD8 effector T cells are reduced; however, Treg cells are increased in the SI and lungs of SHIP1−/− and CD4CreSHIPflox/flox mice. Furthermore, a… CONTINUE READING
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