Impaired Synapse Function during Postnatal Development in the Absence of CALEB, an EGF-like Protein Processed by Neuronal Activity

@article{Juttner2005ImpairedSF,
  title={Impaired Synapse Function during Postnatal Development in the Absence of CALEB, an EGF-like Protein Processed by Neuronal Activity},
  author={Ren{\'e} Ju¨ttner and Margret I. Mor{\'e} and Debashish Das and Aleksei Babich and Jochen Meier and Mechthild Henning and Bettina Erdmann and Eva-Christiana Mu¨ller and Albrecht Otto and Rosemarie Grantyn and Fritz G Rathjen},
  journal={Neuron},
  year={2005},
  volume={46},
  pages={233-245}
}
In an attempt to characterize the molecular components by which electric activity influences the development of synapses, we searched for cell surface proteins modulated by calcium influx and glutamate receptor activity. Here, we report that neuronal depolarization facilitates the conversion of CALEB, which results in a truncated transmembrane form with an exposed EGF domain. To characterize the role of CALEB in synapse development, synaptic features were investigated in slices of the… CONTINUE READING