Impaired Prefronto-Thalamic Functional Connectivity as a Key Feature of Treatment-Resistant Depression: A Combined MEG, PET and rTMS Study

@inproceedings{Li2013ImpairedPF,
  title={Impaired Prefronto-Thalamic Functional Connectivity as a Key Feature of Treatment-Resistant Depression: A Combined MEG, PET and rTMS Study},
  author={Cheng-Ta Li and Li-Fen Chen and Pei-Chi Tu and Shyh-Jen Wang and Mu-Hong Chen and Tung-Ping Su and Jen-Chuen Hsieh},
  booktitle={PloS one},
  year={2013}
}
Prefrontal left-right functional imbalance and disrupted prefronto-thalamic circuitry are plausible mechanisms for treatment-resistant depression (TRD). Add-on repetitive transcranial magnetic stimulation (rTMS), effective in treating antidepressant-refractory TRD, was administered to verify the core mechanisms underlying the refractoriness to antidepressants. Thirty TRD patients received a 2-week course of 10-Hz rTMS to the left dorsolateral prefrontal cortex (DLPFC). Depression scores were… CONTINUE READING
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Development of a rating scale for primary depressive illness

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  • The British journal of social and clinical…
  • 1967
Highly Influential
9 Excerpts

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