Impaired PIASy-Tip60 signaling weakens activation of p53 in melanoma.


The tumor suppressor p53 plays a central role in preventing tumor development by promoting transcription of genes that stall cell cycle and induce cell death. Although the majority of melanomas express wild-type p53, the molecular mechanisms that impede its activation remain unclear. We previously reported that the SUMO E3 ligase PIASy and the histone… (More)
DOI: 10.1097/CMR.0b013e328361056d


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