Impaired Osteoblast Differentiation in Annexin A2- and -A5-Deficient Cells

@inproceedings{Genetos2014ImpairedOD,
  title={Impaired Osteoblast Differentiation in Annexin A2- and -A5-Deficient Cells},
  author={Damian Christopher Genetos and Alice Wong and Thomas Joseph Weber and Norman J. Karin and Clare E. Yellowley},
  booktitle={PloS one},
  year={2014}
}
Annexins are a class of calcium-binding proteins with diverse functions in the regulation of lipid rafts, inflammation, fibrinolysis, transcriptional programming and ion transport. Within bone, they are well-characterized as components of mineralizing matrix vesicles, although little else is known as to their function during osteogenesis. We employed shRNA to generate annexin A2 (AnxA2)- or annexin A5 (AnxA5)-knockdown pre-osteoblasts, and determined whether proliferation or osteogenic… CONTINUE READING

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