Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons

@inproceedings{Latina2017ImpairedNS,
  title={Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons},
  author={Valentina Latina and Silvia Caioli and Cristina Zona and Maria Teresa Ciotti and Giuseppina Amadoro and Pietro Calissano},
  booktitle={Front. Cell. Neurosci.},
  year={2017}
}
Alterations in NGF/TrkA signaling have been suggested to underlie the selective degeneration of the cholinergic basal forebrain neurons occurring in vivo in AD (Counts and Mufson, 2005; Mufson et al., 2008; Niewiadomska et al., 2011) and significant reduction of cognitive decline along with an improvement of cholinergic hypofunction have been found in phase… CONTINUE READING