Impaired NFAT regulation and its role in a severe combined immunodeficiency.

@article{Feske2000ImpairedNR,
  title={Impaired NFAT regulation and its role in a severe combined immunodeficiency.},
  author={Stefan Feske and Ruth Draeger and Hans Hartmut Peter and Anjana Rao},
  journal={Immunobiology},
  year={2000},
  volume={202 2},
  pages={134-50}
}
Severe Combined Immunodeficiency (SCID) is a primary immunodeficiency affecting T cells, B cells, or both. Whereas the clinical symptoms are uniformly dominated by recurrent infections, the molecular causes for SCID are very heterogeneous. Mutations in cell surface receptors, signal transduction molecules and transcription factors have been described, including the common gamma chain of the IL-2 (and IL-4, IL-7, IL-9 and IL-15) receptors, the kinase JAK-3, the epsilon and gamma chains of CD3… CONTINUE READING