Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress

@inproceedings{Jaiswal2015ImpairedME,
  title={Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress},
  author={Manish K Jaiswal and Nele A. Haelterman and Hector Paulo Sandoval and Bo Xiong and Taraka Donti and Auinash Kalsotra and Shinya Yamamoto and Thomas A. Cooper and Brett H Graham and Hugo J. Bellen and Claude Desplan},
  booktitle={PLoS biology},
  year={2015}
}
Two insults often underlie a variety of eye diseases including glaucoma, optic atrophy, and retinal degeneration--defects in mitochondrial function and aberrant Rhodopsin trafficking. Although mitochondrial defects are often associated with oxidative stress, they have not been linked to Rhodopsin trafficking. In an unbiased forward genetic screen designed to isolate mutations that cause photoreceptor degeneration, we identified mutations in a nuclear-encoded mitochondrial gene, ppr, a homolog… CONTINUE READING
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New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models.

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  • 2018
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