Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.

  title={Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.},
  author={Sini Heinonen and Jana Buzkov{\'a} and Maheswary Muniandy and Risto Kaksonen and Miina Ollikainen and Khadeeja Ismail and Antti Hakkarainen and Jesse Lundbom and Nina Lundbom and Katriina Vuolteenaho and Eeva Moilanen and Jaakko Kaprio and Aila M. Rissanen and Anu Suomalainen and Kirsi Hannele Pietil{\"a}inen},
  volume={64 9},
Low mitochondrial number and activity have been suggested as underlying factors in obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which mitochondrial dysfunction manifests in adipose tissue after the onset of obesity remains unknown. Here we examined subcutaneous adipose tissue (SAT) samples from healthy monozygotic twin pairs, 22.8-36.2 years of age, who were discordant (ΔBMI >3 kg/m(2), mean length of discordance 6.3 ± 0.3 years, n = 26) and concordant (ΔBMI <3 kg/m(2… CONTINUE READING
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