Impaired Mechanisms of Leukocyte Adhesion In Vitro by the Calcium Channel Antagonist Mibefradil


In this issue of Cardiovascular Drugs and Therapy, Nebe et al. [1] have demonstrated that the T-type Ca2+-channel blocker mibefradil, but not the L-type Ca2+-channel blockers amlodipine and verapamil, attenuated leukocyte adhesion in vitro. They also observed that mibefradil reduced the surface expression of β2 integrins and L-selectin and inhibited the… (More)
DOI: 10.1023/A:1020694818883