Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.

@article{Davies2014ImpairedJS,
  title={Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.},
  author={Clare C. Davies and Emma Louise Harvey and R. F. T. Mcmahon and Katherine G. Finegan and Frances P. Connor and Roger J Davis and David A Tuveson and Cathy Tournier},
  journal={Cancer research},
  year={2014},
  volume={74 12},
  pages={
          3344-56
        }
}
The c-Jun N-terminal protein kinase (JNK) and its two direct activators, namely the mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) and MKK7, constitute a signaling node frequently mutated in human pancreatic ductal adenocarcinoma (PDAC). Here we demonstrate the cooperative interaction of endogenous expression of Kras(G12D) with loss-of-function mutations in mkk4 or both, mkk4 and mkk7 genes in the pancreas. More specifically, impaired JNK signaling in a subpopulation of Pdx1-expressing… CONTINUE READING
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