Impaired Interleukin-1β and c-Fos Expression in the Hippocampus Is Associated with a Spatial Memory Deficit in P2X7 Receptor-Deficient Mice

@article{Labrousse2009ImpairedIA,
  title={Impaired Interleukin-1β and c-Fos Expression in the Hippocampus Is Associated with a Spatial Memory Deficit in P2X7 Receptor-Deficient Mice},
  author={Virginie F. Labrousse and Laurence Costes and Agn{\`e}s Aubert and Muriel Darnaud{\'e}ry and G Ferreira and Thierry Am{\'e}d{\'e}e and Sophie Lay{\'e}},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={S1 - 13}
}
Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes. We have previously shown that IL-1beta synthesis in the hippocampus is dependent on P2X(7) receptor (P2X(7)R), which is an ionotropic receptor of ATP. To substantiate the role of P2X(7)R in both brain IL-1beta expression and memory processes, we examined the induction of IL-1beta mRNA expression in the hippocampus of wild… CONTINUE READING

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