Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap.

@article{Alalem2005ImpairedIC,
  title={Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap.},
  author={Umaima Al-alem and Cuiling Li and Nathalie Forey and Francis Rom{\'e}o Relouzat and M. -C. Fondaneche and Sean V. Tavtigian and Zhao-Qi Wang and Sylvain Latour and Luo Yin},
  journal={Blood},
  year={2005},
  volume={106 6},
  pages={
          2069-75
        }
}
X-linked lymphoproliferative disease (XLP) is characterized by abnormal immune responses to Epstein-Barr virus attributed to inactivating mutations of the SAP gene. Previous studies showed immunoglobulin E (IgE) deficiency and low serum IgG levels in Sap-deficient mice before and after viral infections, which are associated with impaired CD4+ T-helper function. In the present work, we find that signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is expressed in B cells and… CONTINUE READING

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