Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages

@inproceedings{Neehus2018ImpairedIA,
  title={Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages},
  author={Anna-Lena Neehus and Jenny Lam and Kathrin Haake and Sylvia Merkert and Nico Schmidt and Adele Mucci and Mania Ackermann and Madline Schubert and Christine Happle and Mark Philipp K{\"u}hnel and Patrick Blank and Friederike Philipp and Ralph Goethe and Danny Jonigk and Ulrich Martin and Ulrich Kalinke and Ulrich Baumann and Axel Schambach and Joachim Roesler and Nico Lachmann},
  booktitle={Stem cell reports},
  year={2018}
}
Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from these patients have never been studied. We demonstrate the generation of heterozygous and compound heterozygous (iMSMD-cohet) induced pluripotent stem cells (iPSCs) from a single chimeric patient, who suffered from complete autosomal… CONTINUE READING
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