Impaired Hyperglycemia-Induced Delay in Gastric Emptying in Patients With Type 1 Diabetes Deficient for Islet Amyloid Polypeptide

@article{Woerle2008ImpairedHD,
  title={Impaired Hyperglycemia-Induced Delay in Gastric Emptying in Patients With Type 1 Diabetes Deficient for Islet Amyloid Polypeptide },
  author={Hans J Woerle and Max Albrecht and Rainer Linke and Silvia Zschau and Christoph Neumann and Mathias Nicolaus and John E. Gerich and Burkhard J. G{\"o}ke and J{\"o}rg R. J. Schirra},
  journal={Diabetes Care},
  year={2008},
  volume={31},
  pages={2325 - 2331}
}
OBJECTIVE Slowing of gastric emptying by hyperglycemia, a physiological response to minimize postprandial hyperglycemia, may be impaired in patients with type 1 diabetes. The causes and consequences on glucose homeostasis are unknown. RESEARCH DESIGN AND METHODS Consequences of euglycemia- and hyperglycemia-induced changes in gastric emptying on postprandial glucose fluxes and excursions were studied in 10 healthy subjects and 15 type 1 diabetic subjects after ingestion of a mixed meal using… CONTINUE READING