Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice

@article{McHugh1996ImpairedHR,
  title={Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice},
  author={T. McHugh and K. I. Blum and J. Tsien and S. Tonegawa and M. Wilson},
  journal={Cell},
  year={1996},
  volume={87},
  pages={1339-1349}
}
  • T. McHugh, K. I. Blum, +2 authors M. Wilson
  • Published 1996
  • Biology, Medicine
  • Cell
  • To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus, we have applied multiple electrode recording techniques to freely behaving mice with a CA1 pyramidal cell-specific knockout of the NMDAR1 gene. We have discovered that although the CA1 pyramidal cells of these mice retain place-related activity, there is a significant decrease in the spatial specificity of individual place fields. We have also found a striking deficit in the coordinated firing of… CONTINUE READING

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