Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level

@inproceedings{Paavola2017ImpairedHC,
  title={Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level},
  author={Timo Paavola and Sanna M Kuusisto and Matti Jauhiainen and Sakari Kakko and Tiia Kangas-Kontio and Jari Metso and Pasi Soininen and Mika Ala-Korpela and Risto Bloigu and Minna L. Hannuksela and Markku J. Savolainen and Tuire Salonurmi},
  booktitle={PloS one},
  year={2017}
}
OBJECTIVE The potential of high-density lipoproteins (HDL) to facilitate cholesterol removal from arterial foam cells is a key function of HDL. We studied whether cholesterol efflux to serum and HDL subfractions is impaired in subjects with early coronary heart disease (CHD) or metabolic syndrome (MetS) in families where a low HDL-cholesterol level (HDL-C) predisposes to early CHD. METHODS HDL subfractions were isolated from plasma by sequential ultracentrifugation. THP-1 macrophages loaded… CONTINUE READING

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