Impaired Endothelial Progenitor Cell Mobilization and Dysfunctional Bone Marrow Stroma in Diabetes Mellitus

@inproceedings{Westerweel2013ImpairedEP,
  title={Impaired Endothelial Progenitor Cell Mobilization and Dysfunctional Bone Marrow Stroma in Diabetes Mellitus},
  author={Peter E. Westerweel and Martin Teraa and Shahin Rafii and Janneke E. Jaspers and Ian Alexander White and Andrea T. Hooper and Pieter A. F. M. Doevendans and Marianne C Verhaar},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Circulating Endothelial Progenitor Cell (EPC) levels are reduced in diabetes mellitus. This may be a consequence of impaired mobilization of EPC from the bone marrow. We hypothesized that under diabetic conditions, mobilization of EPC from the bone marrow to the circulation is impaired -at least partly- due to dysfunction of the bone marrow stromal compartment. METHODS Diabetes was induced in mice by streptozotocin injection. Circulating Sca-1(+)Flk-1(+) EPC were characterized and… CONTINUE READING
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