Impaired Development of Early Endometriotic Lesions in CD44 Knockout Mice

@article{Knudtson2016ImpairedDO,
  title={Impaired Development of Early Endometriotic Lesions in CD44 Knockout Mice},
  author={J. Knudtson and R. Tekmal and M. T. Santos and P. Binkley and Naveen K. Krishnegowda and P. Valente and R. Schenken},
  journal={Reproductive Sciences},
  year={2016},
  volume={23},
  pages={87 - 91}
}
Previous studies have shown endometrial cell (EC) CD44 and peritoneal mesothelial cell (PMC)-associated hyaluronan (hyaluronic acid [HA]) are involved in the attachment of endometrial stroma and epithelial cells to peritoneal mesothelium. Here we assess the CD44–HA interaction in the formation of the early endometriotic lesion using CD44–/– (knockout) mice. Using an established murine model and crossover technique, endometrial tissue from donor mice (wild type [WT] and CD44–/–) was used to… Expand
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