Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells.

@article{Kurahashi2009ImpairedDR,
  title={Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells.},
  author={Hiroki Kurahashi and Hidehito Inagaki and Takema Kato and Eriko Hosoba and Hiroshi Kogo and Tamae Ohye and Makiko Tsutsumi and Hasbaira Bolor and Maoqing Tong and Beverly S Emanuel},
  journal={Human molecular genetics},
  year={2009},
  volume={18 18},
  pages={3397-406}
}
Palindromic regions are unstable and susceptible to deletion in prokaryotes and eukaryotes possibly due to stalled or slow replication. In the human genome, they also appear to become partially or completely deleted, while two palindromic AT-rich repeats (PATRR) contribute to known recurrent constitutional translocations. To explore the mechanism that causes the development of palindrome instabilities in humans, we compared the incidence of de novo translocations and deletions at PATRRs in… CONTINUE READING
9 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…