Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus.

  title={Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus.},
  author={Yiqun Zhang and Mingming Zhao and Amr H. Sawalha and Bruce Richardson and Qian-jin Lu},
  journal={Journal of autoimmunity},
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies against a series of nuclear antigens. Although the exact cause of SLE is still unknown, the influence of environment, which is largely reflected by the epigenetic mechanisms, with DNA methylation changes in particular, are generally considered as key players in the pathogenesis of SLE. As an important post-translational modification, DNA methylation mainly suppresses the… CONTINUE READING


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