Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci.

@article{Huber2001ImpairedDD,
  title={Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci.},
  author={L Julie Huber and Thomas J. W. Yang and Christopher J. Sarkisian and Stephen R. Master and Chu Xia Deng and Lewis A. Chodosh},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 12},
  pages={4005-15}
}
Both human and mouse cells express an alternatively spliced variant of BRCA1, BRCA1-Delta11, which lacks exon 11 in its entirety, including putative nuclear localization signals. Consistent with this, BRCA1-Delta11 has been reported to reside in the cytoplasm, a localization that would ostensibly preclude it from playing a role in the nuclear processes in which its full-length counterpart has been implicated. Nevertheless, the finding that murine embryos bearing homozygous deletions of exon 11… CONTINUE READING