Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.

  title={Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy.},
  author={Katharina Klatte and Timo Kirschstein and David M. Otte and Leonie Pothmann and Lorenz M{\"u}ller and Tursonjan Tokay and Maria Kober and Mischa Uebachs and Andreas Zimmer and Heinz Beck},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 32},
The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory site of the receptor. In many forebrain regions, this coagonist is d-serine. Here, we show that experimental epilepsy in rats is associated with a reduction in the CNS levels of d-serine, which leads to a desaturation of the coagonist binding site of synaptic and extrasynaptic… CONTINUE READING
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