Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

@inproceedings{Williams2011ImpairedCD,
  title={Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances},
  author={Brent L Williams and Mady Hornig and Timothy M. Buie and Margaret L. Bauman and Myunghee Cho Paik and Ivan Wick and Ashlee Bennett and Omar Jabado and David L. Hirschberg and W. Ian Lipkin},
  booktitle={PloS one},
  year={2011}
}
Gastrointestinal disturbances are commonly reported in children with autism, complicate clinical management, and may contribute to behavioral impairment. Reports of deficiencies in disaccharidase enzymatic activity and of beneficial responses to probiotic and dietary therapies led us to survey gene expression and the mucoepithelial microbiota in intestinal biopsies from children with autism and gastrointestinal disease and children with gastrointestinal disease alone. Ileal transcripts encoding… CONTINUE READING

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