Impaired CD8+ T-cell reactivity against viral antigens in cancer patients with solid tumors.


BACKGROUND Patients with hematological malignancies are at increased risk for various infections. In patients with solid cancer, a variety of immunosuppressive mechanisms affecting T-cell response are described. We hypothesized that patients with advanced solid tumors may exhibit an impaired recognition of viral antigens. To test this, the capability of CD8… (More)


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